Targeting Stromal Cell Interactions to Reduce Prostate Cancer
Prostate cancer is the second leading cause of cancer-related death in the United States among men and is the most commonly diagnosed cancer in American males. Endoglin is a constituent of the transforming growth factor-beta receptor signaling system that is involved in prostate cancer cell migration, invasion, and metastasis. In an endoglin-dependent mouse model of prostate cancer previously developed with MCF support, we find that mice that are deficient in endoglin develop prostate tumors that lack supporting stromal cells, which arise from the tumor microenvironment. We will use this model of prostate tumor-stromal cell interaction to study the ability of pharmacologic inhibitors of endoglin function to target the prostate cancer microenvironment.