Small Molecule Inhibitors of Twist1 Function to Inhibit Tumor Progression

The Twist1 gene is highly expressed in many different tumor types and regulates several different stages of tumor development, from initiation through metastasis. Loss of Twist1 can prevent tumor progression, and therefore Twist1 represents a promising target for the development of anti-cancer drugs. Dr. Spicer and his team have identified specific protein interactions that are required for Twist1 function. Consequently this project aims to develop primary and secondary assays for high throughput screening to identify small molecule inhibitors of these interactions and to validate these assays with a small-scale screen of 2,000 compounds. The long-range goal is to extend this initial study to a large-scale screen of more than 500,000 compounds in collaboration with the Broad Institute in Boston. There is now a growing literature on the importance of Twist1 in promoting tumor progression in many different tumor types, and therefore an agent targeting Twist1 function would have broad therapeutic value.

Organization: 
Maine Medical Center
Researcher: 
Douglas Spicer
Grant Amount Given: 
$73,039
Year Issued: 
2011
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Molecular
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2016 Building Capacity at MaineHealth to Enahance Colorectal Cancer Screening $28,863 Screening Maine Medical Center
2016 The Maine Lung Cancer Prevention and Screening (Maine LungCAPS) Initiative $400,000 Prevention Maine Medical Center
2015 Extending Lung Cancer Screening to Primary Care $49,899 Screening Maine Medical Center
2013 Lung Cancer Screening Shared Decision-Making $25,536 Screening Maine Medical Center
2013 Endometrial Cancer & Obesity: A Survivorship Program $10,000 Survivorship Maine Medical Center
2012 Improving Colorectal Cencer Screenings in Low-Income Primary Care Settings Using Shared Decision Making $97,860 Research Maine Medical Center
2012 Cancer Survivorship Support $10,000 Survivorship Maine Medical Center
2012 Oncology Pharmacy Practice Residency $5,000 Support Maine Medical Center
2012 Gas Cards for Emergency Aid $1,000 Beacon Fund Maine Medical Center
2012 Inhibitory Effects of Insulin-like Growth Factor Binding Protein-4(IGFBP-4) on Melanoma Growth and Metastasis $73,848 Research Maine Medical Center
2011 FGF Export from Endothelial Cells: Protumorigenic Potential and Methods of Regulation $86,877 Research Maine Medical Center
2011 Validating Prediction Tools for Prostate Cancer Quality of Life Outcomes $71,029 Research Maine Medical Center
2011 Increase Immigrant Screening $8,011 Screening Maine Medical Center
2011 Communicating Risk $9,413 Education Maine Medical Center
2011 Notch Regulation of the Tumor Supressor miR-145 in Breast Cancer Cells $94,184 Research Maine Medical Center
2011 Inceptive Role of miR-199b in Acute Myeloid Leukemia $92,000 Research Maine Medical Center
2011 Small Molecule Inhibitors of Twist1 Function to Inhibit Tumor Progression $73,039 Research Maine Medical Center
2009 Predicting Quality of Life Outcomes after Prostate Cancer Treatment $45,295 Research Maine Medical Center
2006 Reduction of breast cancer by the Notch signaling pathway $35,000 Research Maine Medical Center
2001 Ronald J . Carroll, M.D. Lecture Fund at Maine Medical Center $10,000 Education Maine Medical Center
1979 Pediatric Cancer Seminar Education Maine Medical Center