Notch Regulation of the Tumor Supressor miR-145 in Breast Cancer Cells

Tumor suppressors are protective genes that normally function to inhibit cancer. Recently, a class of genes encoding small RNA molecules, called microRNAs, have been shown to regulate tumor growth. When levels of a tumor suppressor are decreased, cells are more susceptible to becoming cancer. Dr. Liaw’s project focuses on one microRNA, miR-145, which is typically suppressed during cancer. The goal of this project is to understand what activates miR-145 in human breast cancer cells. Dr. Liaw’s research team identified an upstream signaling regulator, called the Notch pathway. Their aim is to understand how Notch activates miR-145 and therefore potentially restore its tumor suppressive activity to inhibit breast cancer growth.

Organization: 
Maine Medical Center
Researcher: 
Lucy Liaw
Grant Amount Given: 
$94,184
Year Issued: 
2011
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Breast
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2016 Building Capacity at MaineHealth to Enahance Colorectal Cancer Screening $28,863 Screening Maine Medical Center
2016 The Maine Lung Cancer Prevention and Screening (Maine LungCAPS) Initiative $400,000 Prevention Maine Medical Center
2015 Extending Lung Cancer Screening to Primary Care $49,899 Screening Maine Medical Center
2013 Lung Cancer Screening Shared Decision-Making $25,536 Screening Maine Medical Center
2013 Endometrial Cancer & Obesity: A Survivorship Program $10,000 Survivorship Maine Medical Center
2012 Improving Colorectal Cencer Screenings in Low-Income Primary Care Settings Using Shared Decision Making $97,860 Research Maine Medical Center
2012 Cancer Survivorship Support $10,000 Survivorship Maine Medical Center
2012 Oncology Pharmacy Practice Residency $5,000 Support Maine Medical Center
2012 Gas Cards for Emergency Aid $1,000 Beacon Fund Maine Medical Center
2012 Inhibitory Effects of Insulin-like Growth Factor Binding Protein-4(IGFBP-4) on Melanoma Growth and Metastasis $73,848 Research Maine Medical Center
2011 FGF Export from Endothelial Cells: Protumorigenic Potential and Methods of Regulation $86,877 Research Maine Medical Center
2011 Validating Prediction Tools for Prostate Cancer Quality of Life Outcomes $71,029 Research Maine Medical Center
2011 Increase Immigrant Screening $8,011 Screening Maine Medical Center
2011 Communicating Risk $9,413 Education Maine Medical Center
2011 Notch Regulation of the Tumor Supressor miR-145 in Breast Cancer Cells $94,184 Research Maine Medical Center
2011 Inceptive Role of miR-199b in Acute Myeloid Leukemia $92,000 Research Maine Medical Center
2011 Small Molecule Inhibitors of Twist1 Function to Inhibit Tumor Progression $73,039 Research Maine Medical Center
2009 Predicting Quality of Life Outcomes after Prostate Cancer Treatment $45,295 Research Maine Medical Center
2006 Reduction of breast cancer by the Notch signaling pathway $35,000 Research Maine Medical Center
2001 Ronald J . Carroll, M.D. Lecture Fund at Maine Medical Center $10,000 Education Maine Medical Center
1979 Pediatric Cancer Seminar Education Maine Medical Center