Improved Cancer Detection through the use of Engineered Nanoparticle Bioconjugates
Accurate and early tumor localization is critical in determining the course of treatment for patients with cancer. However, small or low density tumors are often difficult to distinguish from normal tissues, and hence not observed by imaging studies such as MRI or CT (x-ray). This project involves the development of a new class of cancer identifying agents (pancreas and liver) based on chemically modified metal nanoparticles labeled with bio-active molecules. These particles are non-toxic, can specifically seek out cancer cells and, though only a few billionths of a meter across, generate very strong CT signals.