Genetic Model of TGFB Receptor-Dependent Supression of Prostate Cancer Metastasis
Prostate cancer metastatic disease is the primary cause of prostate cancer-associated mortality. We propose to develop a novel mouse model of prostate cancer metastasis that combines the ability to genetically manipulate the expression of components of the TGF-beta signaling pathway in male mice that are genetically programmed to get metastatic prostate cancer. Patients with prostate cancer suffer a high rate of mortality because of metastatic disease. Our analysis of the signaling pathways involved in the regulation of prostate cancer metastasis will provide a rationale for the design of novel therapeutic approaches that can improve prostate cancer survival.