Array-based Comparative Genomic Hybridization of Circulation Tumor Cells in Breast Cancer Patients Before & During Treatment
Breast cancer is a leading cause of cancer-related death in women under 30, and many of the methods used in its detection and elimination are not evolved enough to detect a relapse, the early detection of which is essential to the prevention a possibly more harmful second bought of cancer in a survivor. Solid tumors , including those of the breast, have been shown to shed neoplastic cells into circulation soon after becoming invasive. These circulating tumor cells (CTCs) are found in a significant proportion of patients when a carcinoma recurs, and cytogenic studies have shown that they are derived from clones in the primary tumor. Thus, the identification of CTCs in peripheral blood may provide an approach to the early assessment of minimal residual disease and treatment efficacy. It is proposed to isolate CTCs from peripheral blood specimens obtained from breast cancer patients at two points in time and to utilize a whole genome amplification technique to generate genomic profiles of the CTCs by array comparative genomic hybridization (aCGH).
Maine Cancer Foundation Grants to this Organization:
|2007||RECQL4 Protein-Protein Interactions in Human Osteosarcoma Cell Lines||$71,000||Research||Eastern Maine Healthcare Systems|
|2007||Array-based Comparative Genomic Hybridization of Circulation Tumor Cells in Breast Cancer Patients Before & During Treatment||$80,000||Research||Eastern Maine Healthcare Systems|
|2007||Prostate||$6,000||Education||Eastern Maine Healthcare Systems|