Validating S100A6 as a Novel Marker and Potential Therapeutic Target of Brain Cancer Stem Cells
In the State of Maine, more people died from brain/nervous system cancer than from ovary or lung cancers in 2007. Currently, there is no effective treatment for many of these patients. Recent discovery of cancer stem cells that are responsible for therapy resistance, tumor recurrence, and metastasis opens up a new avenue of research; however, the paucity of good markers to identify these cells is a major limiting step. This proposal is focused on a new candidate marker (S100A6) we identified. Results from this study have high potential to generate a novel prognostic tool and to identify a novel therapeutic target against cancer stem cells.