Twist dimers as markers of tumor metastasis

This project is specifically aimed at the proliferation of tumor metastasis, which is the leading cause of death due to cancer. Early work done by this team, with a grant from the Maine Cancer Foundation, found a specific transcription factor called Twist. This research revealed that two types of the Twist factor cause opposite affects in tumorous tissue. The homodimer form of Twist (T/T) drives metastasis in a normally non-metastatic tumor, an obviously unwanted effect. The heterodimer (T/E) can inhibit metastasis in a normally very aggressive tumor, a potentially life-saving effect. Because Twist is a transcription factor with multiple potential gene targets, it may be a major regulator of the metastatic phenotype that could be selected as an important therapeutic target. Therefore, the first aim of this study is to generate antibodies that specifically recognize T/T dimers. The second aim of this study is to begin to understand how T/T and T/E differentially regulate gene expression. 

Organization: 
Maine Medical Center Research Institute
Researcher: 
Douglas Spicer
Grant Amount Given: 
$73,000
Year Issued: 
2007
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Molecular
Screening
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2015 Tumor Registry Electronic Medical Record Linked Data Resource: TREMR $191,230 Research Maine Medical Center Research Institute
2015 Integrating Personalized Risk Information in Low-Dose CT (LDCT) Screening for Lung Cancer $100,000 Research Maine Medical Center Research Institute
2015 Creating a Centralized Biospecimen Resource for Cancer Research $199,830 Research Maine Medical Center Research Institute
2014 FOXD1: The Key to Kidney Tumors? $178,409 Research Maine Medical Center Research Institute
2013 Numb5 & Numb6 promote Invasive Behavior of Breast Cancer by Inducing Epithelial-Mesenchymal Transition $49,989 Research Maine Medical Center Research Institute
2013 The Role Of Spry1 And Spry4 In Triple-Negative Breast Cancer Differentiation And Cancer Stem Cell Self-Renewal $156,315 Research Maine Medical Center Research Institute
2013 Development of a Novel Small Molecule Inhibitor for Breast Cancer Treatment $169,861 Research Maine Medical Center Research Institute
2013 miR-590 - A Novel Candidate microRNA in Acute Myeloid Leukemia $168,906 Research Maine Medical Center Research Institute
2013 Notch Signaling In A Mouse Model Of Acute Promyelocytic Leukemia $50,000 Research Maine Medical Center Research Institute
2011 Passport to Care $10,000 Navigator Maine Medical Center Research Institute
2010 Targeting Stromal Cell Interactions to Reduce Prostate Cancer $81,175 Research Maine Medical Center Research Institute
2010 Regulation of Hematopoietic Stem Cells by Heparin Binding Domain of IGFBP-2 $82,535 Research Maine Medical Center Research Institute
2010 Role of Cryptic Activation Site within B1 Integrins in Breast Tumor Growth $91,919 Research Maine Medical Center Research Institute
2009 Functional Tests of PODXL's Contributions to Tumorigenesis $80,000 Research Maine Medical Center Research Institute
2008 Genetic Model of TGFB Receptor-Dependent Supression of Prostate Cancer Metastasis $78,413 Research Maine Medical Center Research Institute
2008 FGF-Mediated Tumor Growth Induced by Noth Signaling Inhibition $86,191 Research Maine Medical Center Research Institute
2007 Sprouty 4: a possible repressor of Id protein function in breast cancer $72,000 Research Maine Medical Center Research Institute
2007 Twist dimers as markers of tumor metastasis $73,000 Research Maine Medical Center Research Institute