Targeted SiRNA Inhibition of Vascular Endothelial Growth Factors in Lung Cancer Cells

Vascular endothelial growth factor (VEGF) plays a crucial role in cancer cell growth and tumor expansion. Inhibition of VEGF overexpression offers a potential target for cancer therapy. Dr. Bai will identify nanoparticle based small interfering RNAs (SiRNAs) for targeting prevention of VEGF expression in lung tumors. This work will aim at providing important new data on a safe and effective therapeutic approach to lung cancer using gene therapy and nanotechnology to improve the effectiveness of the treatment efficacy while limiting the toxicity. In addition, this work will help develop general principles that can be applied toward the establishment of nanoparticles as a platform technology for delivering targeted gene silencing therapies against other cancers.

Husson University
Shuhua Bai, Ph.D.
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1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization: