Role of MicroRNA-10b in Neurofibromatosis Type 1 Tumorigenesis and Progression

Neurofibromatosis type 1 (NF1) is the most common inherited tumor predisposition syndrome that occurs in about 1:3500 live births. NF1 individuals are at high risk of developing benign and malignant tumors, such as malignant peripheral nerve sheath tumors (MPNST). The prognosis for patients with MPNST is poor, with a 5-year survival rate of just 34%. Thus new, effective therapies are urgently needed. We have found that a small intracellular regulator molecule, miRNA-10b, was dramatically increased in cells and tumor tissues from MPNST. We hypothesize that miRNA-10b is critical for the development of MPNST. The purpose of the proposed studies is to inhibit miRNA-10b in MPNST cells and determine if it can reduce tumor formation. This proposal will help determine the role of miR-10b in the development of MPNST. miRNA-10b may represent a diagnostic marker and a target for prevention and treatment of MPNST in NF1.

Organization: 
Maine Institute for Human Genetics and Health
Researcher: 
Xijie Yu
Grant Amount Given: 
$72,059
Year Issued: 
2009
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Cellular
Molecular
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2011 The Molecular Structor of Arm 1 $73,087 Research Maine Institute for Human Genetics and Health
2009 Role of MicroRNA-10b in Neurofibromatosis Type 1 Tumorigenesis and Progression $72,059 Research Maine Institute for Human Genetics and Health