Role of MicroRNA-10b in Neurofibromatosis Type 1 Tumorigenesis and Progression
Neurofibromatosis type 1 (NF1) is the most common inherited tumor predisposition syndrome that occurs in about 1:3500 live births. NF1 individuals are at high risk of developing benign and malignant tumors, such as malignant peripheral nerve sheath tumors (MPNST). The prognosis for patients with MPNST is poor, with a 5-year survival rate of just 34%. Thus new, effective therapies are urgently needed. We have found that a small intracellular regulator molecule, miRNA-10b, was dramatically increased in cells and tumor tissues from MPNST. We hypothesize that miRNA-10b is critical for the development of MPNST. The purpose of the proposed studies is to inhibit miRNA-10b in MPNST cells and determine if it can reduce tumor formation. This proposal will help determine the role of miR-10b in the development of MPNST. miRNA-10b may represent a diagnostic marker and a target for prevention and treatment of MPNST in NF1.
Maine Cancer Foundation Grants to this Organization:
|2011||The Molecular Structor of Arm 1||$73,087||Research||Maine Institute for Human Genetics and Health|
|2009||Role of MicroRNA-10b in Neurofibromatosis Type 1 Tumorigenesis and Progression||$72,059||Research||Maine Institute for Human Genetics and Health|