Role of Cryptic Activation Site within B1 Integrins in Breast Tumor Growth

Recent studies suggest that a group of molecules call Integrins play critical roles in breast cancer and some work has suggested that they may actually reduce the effectiveness of certain types of chemotherapy. Our laboratory has generated an antibody that only recognizes an activated form of these molecules. The unique characteristics of this new antibody (FM155) allow us the opportunity to target these Integrins in a highly selective manner. Thus, we have proposed to evaluate the effects of combining FM155 with chemotherapy to examine whether this unique strategy may enhance the effectiveness of existing therapy for the treatment breast cancer.

Organization: 
Maine Medical Center Research Institute
Researcher: 
Peter C. Brooks, Ph.D
Grant Amount Given: 
$91,919
Year Issued: 
2010
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Breast
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2015 Creating a Centralized Biospecimen Resource for Cancer Research $199,830 Research Maine Medical Center Research Institute
2015 Tumor Registry Electronic Medical Record Linked Data Resource: TREMR $191,230 Research Maine Medical Center Research Institute
2015 Integrating Personalized Risk Information in Low-Dose CT (LDCT) Screening for Lung Cancer $100,000 Research Maine Medical Center Research Institute
2014 FOXD1: The Key to Kidney Tumors? $178,409 Research Maine Medical Center Research Institute
2013 Development of a Novel Small Molecule Inhibitor for Breast Cancer Treatment $169,861 Research Maine Medical Center Research Institute
2013 miR-590 - A Novel Candidate microRNA in Acute Myeloid Leukemia $168,906 Research Maine Medical Center Research Institute
2013 Notch Signaling In A Mouse Model Of Acute Promyelocytic Leukemia $50,000 Research Maine Medical Center Research Institute
2013 Numb5 & Numb6 promote Invasive Behavior of Breast Cancer by Inducing Epithelial-Mesenchymal Transition $49,989 Research Maine Medical Center Research Institute
2013 The Role Of Spry1 And Spry4 In Triple-Negative Breast Cancer Differentiation And Cancer Stem Cell Self-Renewal $156,315 Research Maine Medical Center Research Institute
2011 Passport to Care $10,000 Navigator Maine Medical Center Research Institute
2010 Regulation of Hematopoietic Stem Cells by Heparin Binding Domain of IGFBP-2 $82,535 Research Maine Medical Center Research Institute
2010 Role of Cryptic Activation Site within B1 Integrins in Breast Tumor Growth $91,919 Research Maine Medical Center Research Institute
2010 Targeting Stromal Cell Interactions to Reduce Prostate Cancer $81,175 Research Maine Medical Center Research Institute
2009 Functional Tests of PODXL's Contributions to Tumorigenesis $80,000 Research Maine Medical Center Research Institute
2008 FGF-Mediated Tumor Growth Induced by Noth Signaling Inhibition $86,191 Research Maine Medical Center Research Institute
2008 Genetic Model of TGFB Receptor-Dependent Supression of Prostate Cancer Metastasis $78,413 Research Maine Medical Center Research Institute
2007 Twist dimers as markers of tumor metastasis $73,000 Research Maine Medical Center Research Institute
2007 Sprouty 4: a possible repressor of Id protein function in breast cancer $72,000 Research Maine Medical Center Research Institute