Reduction of breast cancer by the Notch signaling pathway

The goal of this project is to understand how Notch receptor signaling regulates breast cancer growth and metastasis. It is hypothesized that the unique signaling pathways of Notch4 (tumor promoter) versus Notch2 (tumor suppressor) in breast cancer are mediated by distinct structural domains in the intracellular domains, and the activation of unique gene targets. The goals of this project include: To define sequences within the Notch4 and Notch2 receptors that confer tumor-promoting or tumor-suppressing activity, respectively, using human breast cancer cells in vitro; to use gene chip microarray to identify gene target of Notch1, Notch2, and Notch4 in the following target cells: human breast carcinoma cells, endothelial cells, and smooth muscle cells; and to continue to build the system for the quantitative analysis of breast cancer metastasis in our existing xenograft models. 

Organization: 
Maine Medical Center
Researcher: 
Lucy Liaw
Grant Amount Given: 
$35,000
Year Issued: 
2006
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Breast
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2016 Building Capacity at MaineHealth to Enahance Colorectal Cancer Screening $28,863 Screening Maine Medical Center
2016 The Maine Lung Cancer Prevention and Screening (Maine LungCAPS) Initiative $400,000 Prevention Maine Medical Center
2015 Extending Lung Cancer Screening to Primary Care $49,899 Screening Maine Medical Center
2013 Lung Cancer Screening Shared Decision-Making $25,536 Screening Maine Medical Center
2013 Endometrial Cancer & Obesity: A Survivorship Program $10,000 Survivorship Maine Medical Center
2012 Gas Cards for Emergency Aid $1,000 Beacon Fund Maine Medical Center
2012 Inhibitory Effects of Insulin-like Growth Factor Binding Protein-4(IGFBP-4) on Melanoma Growth and Metastasis $73,848 Research Maine Medical Center
2012 Improving Colorectal Cencer Screenings in Low-Income Primary Care Settings Using Shared Decision Making $97,860 Research Maine Medical Center
2012 Cancer Survivorship Support $10,000 Survivorship Maine Medical Center
2012 Oncology Pharmacy Practice Residency $5,000 Support Maine Medical Center
2011 Small Molecule Inhibitors of Twist1 Function to Inhibit Tumor Progression $73,039 Research Maine Medical Center
2011 Validating Prediction Tools for Prostate Cancer Quality of Life Outcomes $71,029 Research Maine Medical Center
2011 FGF Export from Endothelial Cells: Protumorigenic Potential and Methods of Regulation $86,877 Research Maine Medical Center
2011 Communicating Risk $9,413 Education Maine Medical Center
2011 Increase Immigrant Screening $8,011 Screening Maine Medical Center
2011 Notch Regulation of the Tumor Supressor miR-145 in Breast Cancer Cells $94,184 Research Maine Medical Center
2011 Inceptive Role of miR-199b in Acute Myeloid Leukemia $92,000 Research Maine Medical Center
2009 Predicting Quality of Life Outcomes after Prostate Cancer Treatment $45,295 Research Maine Medical Center
2006 Reduction of breast cancer by the Notch signaling pathway $35,000 Research Maine Medical Center
2001 Ronald J . Carroll, M.D. Lecture Fund at Maine Medical Center $10,000 Education Maine Medical Center
1979 Pediatric Cancer Seminar Education Maine Medical Center