Numb5 & Numb6 promote Invasive Behavior of Breast Cancer by Inducing Epithelial-Mesenchymal Transition

Breast cancer is the most common neoplastic disease worldwide and the number one cause of cancerrelated death among non-smoking women in the USA (1-2). Tumor invasion and metastasis are the major causes of cancer mortality. Detection and treatment of metastatic breast cancer requires a better understanding of the mechanisms that cause breast tumor cells to become invasive.

Treatment of metastatic breast cancer generally focuses on relieving symptoms and extending a patient’s life. To improve treatment outcomes and clinical decision-making, identification of novel pro-invasive protein targets is necessary. Despite strong interest in such biomarkers, the number of clinical assays available in oncology remains very small and rapid appraisal of new candidate prognostic and predictive markers in breast cancer is critical. This research project is based on the discovery of novel proteins, Numb5 and Numb6, which are produced in breast cancer, but not normal breast tissue. Our preliminary studies show that Numb5 and Numb6 can change the behavior of human breast cancer cells into a more malignant tumor type.

Our goal is to study how Numb5 and Numb6 change breast cancer cell behavior, and screen cases of human breast cancer to determine a relationship of Numb5 and Numb6 to the malignant phenotype. Our project addresses Numb5 and Numb6 as both novel therapeutic and diagnostic targets in human breast cancer.

Organization: 
Maine Medical Center Research Institute
Researcher: 
Aldona A Karaczyn, Ph.D
Grant Amount Given: 
$49,989
Year Issued: 
2013
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Breast
Cellular
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2015 Tumor Registry Electronic Medical Record Linked Data Resource: TREMR $191,230 Research Maine Medical Center Research Institute
2015 Integrating Personalized Risk Information in Low-Dose CT (LDCT) Screening for Lung Cancer $100,000 Research Maine Medical Center Research Institute
2015 Creating a Centralized Biospecimen Resource for Cancer Research $199,830 Research Maine Medical Center Research Institute
2014 FOXD1: The Key to Kidney Tumors? $178,409 Research Maine Medical Center Research Institute
2013 Numb5 & Numb6 promote Invasive Behavior of Breast Cancer by Inducing Epithelial-Mesenchymal Transition $49,989 Research Maine Medical Center Research Institute
2013 The Role Of Spry1 And Spry4 In Triple-Negative Breast Cancer Differentiation And Cancer Stem Cell Self-Renewal $156,315 Research Maine Medical Center Research Institute
2013 Development of a Novel Small Molecule Inhibitor for Breast Cancer Treatment $169,861 Research Maine Medical Center Research Institute
2013 miR-590 - A Novel Candidate microRNA in Acute Myeloid Leukemia $168,906 Research Maine Medical Center Research Institute
2013 Notch Signaling In A Mouse Model Of Acute Promyelocytic Leukemia $50,000 Research Maine Medical Center Research Institute
2011 Passport to Care $10,000 Navigator Maine Medical Center Research Institute
2010 Targeting Stromal Cell Interactions to Reduce Prostate Cancer $81,175 Research Maine Medical Center Research Institute
2010 Regulation of Hematopoietic Stem Cells by Heparin Binding Domain of IGFBP-2 $82,535 Research Maine Medical Center Research Institute
2010 Role of Cryptic Activation Site within B1 Integrins in Breast Tumor Growth $91,919 Research Maine Medical Center Research Institute
2009 Functional Tests of PODXL's Contributions to Tumorigenesis $80,000 Research Maine Medical Center Research Institute
2008 Genetic Model of TGFB Receptor-Dependent Supression of Prostate Cancer Metastasis $78,413 Research Maine Medical Center Research Institute
2008 FGF-Mediated Tumor Growth Induced by Noth Signaling Inhibition $86,191 Research Maine Medical Center Research Institute
2007 Sprouty 4: a possible repressor of Id protein function in breast cancer $72,000 Research Maine Medical Center Research Institute
2007 Twist dimers as markers of tumor metastasis $73,000 Research Maine Medical Center Research Institute