Notch Signaling In A Mouse Model Of Acute Promyelocytic Leukemia
The Notch signaling pathway is an evolutionarily-conserved mechanism for cells in the body to communicate with one another. Mutations in Notch signaling pathway components have been found in a variety of cancers. Very recent work has demonstrated an important role for Notch signaling in Acute Promyelocytic Leukemia.
In this pilot project proposal, we will assess whether we can generate, using publicly available mouse resources, a new model that exhibits rapid and complete induction of Acute Promyelocytic Leukemia, and whether this model also is dependent on Notch signaling. This work could help provide new therapeutic avenues for treating Acute Promyelocytic Leukemia patients with relapsed or refractory disease.