Notch Signaling in Medulloblastoma Initiation and Cancer Stem Cell Maintenance
According to a recent report by the Center for Disease Control, Maine has the highest incidence rate for brain cancer among the 50 states. This study focuses on medulloblastoma, the most common pediatric brain tumor, with the goal of elucidating the role of the Notch signaling pathway in medulloblastoma formation, maintenance, therapy resistance, and recurrence. We will analyze cancer stem cells (cells responsible for therapy resistance and tumor recurrence) from a new mouse model we generated and medulloblastoma patient samples. We anticipate that our findings will provide new insights into cancer stem cells in medulloblastomas and reveal molecular characteristics of a medulloblastoma subtype, knowledge that can be used to improve diagnosis and patient management strategies.