MicroRNA Expression during Lung Tumor Progression
Lung cancer is the leading cause of cancer deaths worldwide. The genes and mechanisms that mediate metastasis, or spread, of pulmonary adenocarcinoma, the most common type of lung cancer, are poorly understood. The objective of our work is to identify which microRNAs are present and how their abundance and function changes during the progression from early-stage to late-stage pulmonary adenocarcinoma. MicroRNAs are a class of recently discovered small, regulatory molecules. Knowledge of which genes and molecular pathways are important during tumor progression will lay the foundation for predicting which lung tumors are likely to become metastatic and for identifying molecules for chemotherapeutic intervention.