Improved Cancer Detection through the use of Engineered Nanoparticle Bioconjugates

Accurate and early tumor localization is critical in determining the course of treatment for patients with cancer. However, small or low density tumors are often difficult to distinguish from normal tissues, and hence not observed by imaging studies such as MRI or CT (x-ray). This project involves the development of a new class of cancer identifying agents (pancreas and liver) based on chemically modified metal nanoparticles labeled with bio-active molecules. These particles are non-toxic, can specifically seek out cancer cells and, though only a few billionths of a meter across, generate very strong CT signals.

Organization: 
University of Maine
Researcher: 
Michael Mason, Ph.D
Grant Amount Given: 
$78,292
Year Issued: 
2009
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Screening
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2014 Catching Cancer Before It Appears $172,512 Research University of Maine
2014 Panning for Gold: Nanomaterials & the Future of Cancer Treatment $168,309 Research University of Maine
2012 Development of a Cancer Staging Tool Based on Viscoelastic and Spectrosphic Properties of Cystic Fluids $75,422 Research University of Maine
2012 3DMammoComp: Next Generation Computational Analysis of Breast Tomosynthesis $82,843 Research University of Maine
2010 Computational Pathology: 3-d Analysis of Chromosome Territories $80,000 Research University of Maine
2009 Improved Cancer Detection through the use of Engineered Nanoparticle Bioconjugates $78,292 Research University of Maine
2008 Wavelet-based image analysis of Mammograms $73,552 Research University of Maine
2006 Preventive and Therapeutic Effects of Vitamin D3 an its Membrane Receptor on Neoplastic Cells $76,206 Research University of Maine
2004 Mechanisms of Arsenic Induced Human Lung and Bladder Cancer $45,745 Research University of Maine
2003 Protein Palmyitoylation: Examination and Characterization of the Protein Palitoyl-CoA Transferase Family of Dictyostelium $17,640 Research University of Maine
2001 The New Biology at USM $1,230 Education University of Maine