Homologous Recombination Factor XRCC2 in B-Cell Genome Stability and Tumor Supression
According to estimates by the Maine Cancer Registry and the National Cancer Institute there are more than 700 new leukemia and lymphoma cases, and over 220 leukemia or lymphoma-related deaths, yearly in Maine. Chromosome abnormalities – such as broken chromosomes, rearrangements, and exchanges of material between different chromosomes – are hallmarks of leukemia and lymphoma. This project aims to identify and investigate the cellular processes that normally protect against cancer-related chromosome rearrangements. This work will be essential to 1) understanding the origins of chromosome abnormalities and how they may lead to cancer; and 2) developing better diagnosis and/or treatment strategies.