Genetic Model of TGFB Receptor-Dependent Supression of Prostate Cancer Metastasis

Prostate cancer metastatic disease is the primary cause of prostate cancer-associated mortality. We propose to develop a novel mouse model of prostate cancer metastasis that combines the ability to genetically manipulate the expression of components of the TGF-beta signaling pathway in male mice that are genetically programmed to get metastatic prostate cancer. Patients with prostate cancer suffer a high rate of mortality because of metastatic disease. Our analysis of the signaling pathways involved in the regulation of prostate cancer metastasis will provide a rationale for the design of novel therapeutic approaches that can improve prostate cancer survival.

Organization: 
Maine Medical Center Research Institute
Researcher: 
Calvin Vary
Grant Amount Given: 
$78,413
Year Issued: 
2008
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Prostate
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2015 Tumor Registry Electronic Medical Record Linked Data Resource: TREMR $191,230 Research Maine Medical Center Research Institute
2015 Integrating Personalized Risk Information in Low-Dose CT (LDCT) Screening for Lung Cancer $100,000 Research Maine Medical Center Research Institute
2015 Creating a Centralized Biospecimen Resource for Cancer Research $199,830 Research Maine Medical Center Research Institute
2014 FOXD1: The Key to Kidney Tumors? $178,409 Research Maine Medical Center Research Institute
2013 Numb5 & Numb6 promote Invasive Behavior of Breast Cancer by Inducing Epithelial-Mesenchymal Transition $49,989 Research Maine Medical Center Research Institute
2013 The Role Of Spry1 And Spry4 In Triple-Negative Breast Cancer Differentiation And Cancer Stem Cell Self-Renewal $156,315 Research Maine Medical Center Research Institute
2013 Development of a Novel Small Molecule Inhibitor for Breast Cancer Treatment $169,861 Research Maine Medical Center Research Institute
2013 miR-590 - A Novel Candidate microRNA in Acute Myeloid Leukemia $168,906 Research Maine Medical Center Research Institute
2013 Notch Signaling In A Mouse Model Of Acute Promyelocytic Leukemia $50,000 Research Maine Medical Center Research Institute
2011 Passport to Care $10,000 Navigator Maine Medical Center Research Institute
2010 Targeting Stromal Cell Interactions to Reduce Prostate Cancer $81,175 Research Maine Medical Center Research Institute
2010 Regulation of Hematopoietic Stem Cells by Heparin Binding Domain of IGFBP-2 $82,535 Research Maine Medical Center Research Institute
2010 Role of Cryptic Activation Site within B1 Integrins in Breast Tumor Growth $91,919 Research Maine Medical Center Research Institute
2009 Functional Tests of PODXL's Contributions to Tumorigenesis $80,000 Research Maine Medical Center Research Institute
2008 Genetic Model of TGFB Receptor-Dependent Supression of Prostate Cancer Metastasis $78,413 Research Maine Medical Center Research Institute
2008 FGF-Mediated Tumor Growth Induced by Noth Signaling Inhibition $86,191 Research Maine Medical Center Research Institute
2007 Sprouty 4: a possible repressor of Id protein function in breast cancer $72,000 Research Maine Medical Center Research Institute
2007 Twist dimers as markers of tumor metastasis $73,000 Research Maine Medical Center Research Institute