Functional Analysis of Foxq1's Role in Tumor Vascularization
Tumor growth relies on access to the circulatory system, which it achieves by a process called angiogenesis. The resulting vascularization of the tumor provides the necessary nutrients for growth and spread (i.e., metastasis) to other regions of the body. Understanding the molecular basis of angiogenesis is an important area of cancer research. Foxq1 is a nuclear protein that is misregulated in several human cancers and Dr. Planchart’s work in zebrafish has uncovered a potential role for Foxq1 in regulating angiogenesis. Mount Desert Biological Laboratory is taking advantage of the transparency of zebrafish embryos to visualize angiogenesis in real time, in order to understand the role of Foxq1 in this process. Their long-term objective is to understand the molecular pathways leading to tumor vascularization in order to develop strategies to block it, thus starving the tumor and preventing its spread.
Maine Cancer Foundation Grants to this Organization:
|2011||Functional Analysis of Foxq1's Role in Tumor Vascularization||$75,823||Research||Mount Desert Island Biological Laboratory|