FGF-Mediated Tumor Growth Induced by Noth Signaling Inhibition
Tumor increase depends on growth of vessels, which provide tumors with oxygen and nutrients. Fibroblast growth factors (FGF) are strong stimulators of vessel growth. Notch signaling system regulates cell fate at all stages of organism development. We found that Notch signaling inhibition, which can occur in some tumor types, results in the increase of production and secretion of FGF1. The aims of our project are to understand the role of FGF1 in tumor growth stimulated by the inhibition of Notch signaling and to assess the carcinogenic activity of gamma secretase inhibitors, potential anti-Alzheimer drugs, which block Notch signaling.