Development of a Novel Small Molecule Inhibitor for Breast Cancer Treatment

Our proposal seeks to examine whether a small molecule termed C45Na, developed in our lab, may represent an innovative new therapeutic for the treatment of breast cancer. Establishing an understanding of the molecular mechanisms by which C45Na may impact tumor progression is crucial to optimizing its use as a new breast cancer therapeutic in human clinical trials. Therefore, the ultimate goal of these studies is to rigorously establish the scientific proof of concept for the therapeutic activity of C45Na in breast cancer and uncover mechanisms of action of this compound.

These studies will be used in conjunction with additional data, including toxicology and pharmacological studies to support the future filing of an Investigational New Drug (IND) application to the FDA for the testing of C45Na in a human clinical study. Moreover, beyond establishing scientific justification for clinical testing, the studies will serve to generate experimental data needed to support grant applications aimed at a more comprehensive mechanistic evaluation of the effects of C45Na alone and in combination with standard of care treatments for breast cancer.

Organization: 
Maine Medical Center Research Institute
Researcher: 
Peter C. Brooks, Ph.D
Grant Amount Given: 
$169,861
Year Issued: 
2013
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Breast
Molecular
Grant Duration: 
2 Year Accelerator Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2015 Creating a Centralized Biospecimen Resource for Cancer Research $199,830 Research Maine Medical Center Research Institute
2015 Tumor Registry Electronic Medical Record Linked Data Resource: TREMR $191,230 Research Maine Medical Center Research Institute
2015 Integrating Personalized Risk Information in Low-Dose CT (LDCT) Screening for Lung Cancer $100,000 Research Maine Medical Center Research Institute
2014 FOXD1: The Key to Kidney Tumors? $178,409 Research Maine Medical Center Research Institute
2013 miR-590 - A Novel Candidate microRNA in Acute Myeloid Leukemia $168,906 Research Maine Medical Center Research Institute
2013 Notch Signaling In A Mouse Model Of Acute Promyelocytic Leukemia $50,000 Research Maine Medical Center Research Institute
2013 Numb5 & Numb6 promote Invasive Behavior of Breast Cancer by Inducing Epithelial-Mesenchymal Transition $49,989 Research Maine Medical Center Research Institute
2013 The Role Of Spry1 And Spry4 In Triple-Negative Breast Cancer Differentiation And Cancer Stem Cell Self-Renewal $156,315 Research Maine Medical Center Research Institute
2013 Development of a Novel Small Molecule Inhibitor for Breast Cancer Treatment $169,861 Research Maine Medical Center Research Institute
2011 Passport to Care $10,000 Navigator Maine Medical Center Research Institute
2010 Role of Cryptic Activation Site within B1 Integrins in Breast Tumor Growth $91,919 Research Maine Medical Center Research Institute
2010 Targeting Stromal Cell Interactions to Reduce Prostate Cancer $81,175 Research Maine Medical Center Research Institute
2010 Regulation of Hematopoietic Stem Cells by Heparin Binding Domain of IGFBP-2 $82,535 Research Maine Medical Center Research Institute
2009 Functional Tests of PODXL's Contributions to Tumorigenesis $80,000 Research Maine Medical Center Research Institute
2008 Genetic Model of TGFB Receptor-Dependent Supression of Prostate Cancer Metastasis $78,413 Research Maine Medical Center Research Institute
2008 FGF-Mediated Tumor Growth Induced by Noth Signaling Inhibition $86,191 Research Maine Medical Center Research Institute
2007 Twist dimers as markers of tumor metastasis $73,000 Research Maine Medical Center Research Institute
2007 Sprouty 4: a possible repressor of Id protein function in breast cancer $72,000 Research Maine Medical Center Research Institute