Development of a Novel Small Molecule Inhibitor for Breast Cancer Treatment
Our proposal seeks to examine whether a small molecule termed C45Na, developed in our lab, may represent an innovative new therapeutic for the treatment of breast cancer. Establishing an understanding of the molecular mechanisms by which C45Na may impact tumor progression is crucial to optimizing its use as a new breast cancer therapeutic in human clinical trials. Therefore, the ultimate goal of these studies is to rigorously establish the scientific proof of concept for the therapeutic activity of C45Na in breast cancer and uncover mechanisms of action of this compound.
These studies will be used in conjunction with additional data, including toxicology and pharmacological studies to support the future filing of an Investigational New Drug (IND) application to the FDA for the testing of C45Na in a human clinical study. Moreover, beyond establishing scientific justification for clinical testing, the studies will serve to generate experimental data needed to support grant applications aimed at a more comprehensive mechanistic evaluation of the effects of C45Na alone and in combination with standard of care treatments for breast cancer.