Defining Susceptibility To Transformation By Epigenetic Landscape

Acute myeloid leukemia (AML) accounts for 90% of all acute leukemias in adults and 5% of all cancers in children. Intensive chemotherapy remains the universal treatment strategy, but the majority of patients will ultimately relapse and die from their disease. In recent estimates by the Maine Cancer Registry and the National Cancer Institute focused on the State of Maine, ~200 new cases of leukemia are diagnosed per year and more than 100 people die from complications of leukemia, clearly demonstrating that more effective treatments are needed for these patients. In this pilot grant, we propose to take the first steps toward understanding what makes certain leukemias more aggressive or more resistant to chemotherapy than others.

We are looking at this in a new way, by studying whether leukemia aggressiveness or resistance to treatment is based on the type of blood cell that the leukemia comes from. We will use this knowledge to develop personalized cancer therapy, to create new tests that will accurately predict whether a individual’s leukemia will respond to chemotherapy, and if not, to design new drugs to give to patients that will make their leukemia more susceptible to current therapy. These results will directly impact both cancer care and diagnosis in Maine.

Organization: 
The Jackson Laboratory
Researcher: 
Jennifer Trowbridge, Ph.D
Grant Amount Given: 
$49,999
Year Issued: 
2013
Period: 
Annual
Grant Category: 
Research
Types of Cancer: 
Leukemia
Grant Duration: 
1 Year Pilot Grant

Maine Cancer Foundation Grants to this Organization:

Year Program Amount Category Organization
2014 Are Micro RNAs the Key to Stopping Lung Cancer? $50,000 Research The Jackson Laboratory
2014 Mouse Models for Acute Myeloid Leukemia $169,834 Research The Jackson Laboratory
2014 A Slice of Life: The Search for Variation in Brain Tumors $50,000 Research The Jackson Laboratory
2014 Genetic Testing for Primary Care Providers: Case-based Web Modules $49,220 Education The Jackson Laboratory
2014 A Secondary Syndrome: Acute Myeloid Leukemia $50,000 Research The Jackson Laboratory
2013 Defining Susceptibility To Transformation By Epigenetic Landscape $49,999 Research The Jackson Laboratory
2013 The Maine Triple-Negative Breast Cancer Study $212,601 Research The Jackson Laboratory
2013 Assessing Therapeutic Potential of a New Drug ICG-001 in Glioblastoma $50,000 Research The Jackson Laboratory
2013 Development of Optimized Ex Vivo Organotypic Slice Culture Systems $164,686 Research The Jackson Laboratory
2012 New Models for Lung Cancer Research $199,036 Research The Jackson Laboratory
2012 Online CME Course $27,600 Education The Jackson Laboratory
2012 FoxC2 Function in glioma stem cells and Vasculature $84,000 Research The Jackson Laboratory
2011 Imaging Glicoma Stem Cell Dynamics in Vivo $90,000 Research The Jackson Laboratory
2010 Genetic Chemotherapy: Inducing Leukemia and Lymphoma Cell Self Destruction $67,500 Research The Jackson Laboratory
2010 Notch Signaling in Medulloblastoma Initiation and Cancer Stem Cell Maintenance $90,000 Research The Jackson Laboratory
2010 MicroRNA Expression during Lung Tumor Progression $90,000 Research The Jackson Laboratory
2009 Validating S100A6 as a Novel Marker and Potential Therapeutic Target of Brain Cancer Stem Cells $80,000 Research The Jackson Laboratory
2008 Homologous Recombination Factor XRCC2 in B-Cell Genome Stability and Tumor Supression $79,696 Research The Jackson Laboratory
2008 Development Genomics of Lung Cancer $79,524 Research The Jackson Laboratory
2006 Chromatin Reorganization in Pro-B Cell Lymphoma Nuclei $74,180 Research The Jackson Laboratory
2006 The Role of Src Kinases in Regulation of Stem Cell Survival in CML $75,000 Research The Jackson Laboratory
2005 A Gene Expression Study for the Hormone Independent Growth Transition of Ovarian Cancer Cells in vivo $20,000 Research The Jackson Laboratory
2004 Malignant Ovarian Granulose Cell Teumorigenesis $37,165 Research The Jackson Laboratory
2003 Parent-of-Origin Genetics in a Model of Ovarian Ganulosa Cell Tumorigenesis $35,500 Research The Jackson Laboratory